Glioblastoma is an aggressive and heterogeneous tumor in which glioblastoma stem cells (GSCs) are at the apex of an entropic hierarchy and impart devastating therapy resistance. The high entropy of GSCs is driven by a permissive epigenetic landscape and a mutational landscape that revokes crucial cellular checkpoints.

Bao S, Wu Q, McLendon RE, et al. Glioma stem cells promote radioresistance by preferential activation of the DNA damage response. Nature 2006;444:756-60. Liu G, Yuan X, Zeng Z, et al. Analysis of gene expression and chemoresistance of CD133+ cancer stem cells in glioblastoma. Mol Cancer 2006;5:67.

2017-10-09 · Glioma stem cells promote radioresistance by preferential activation of the DNA damage response. Nature 2006; 444 : 756–760. CAS Article Google Scholar In response to DNA damage, normal cells activate the DNA damage response (DDR), utilizing a variety of DNA damage sensing and repair pathways (e.g., base excision repair, nucleotide excision repair, homologous recombination, nonhomologous end-joining, mis-match repair, direct reversal) to maintain genomic integrity, whereas the inability to View 0 peer reviews of Glioma stem cells promote radioresistance by preferential activation of the DNA damage response on Publons Download Web of Science™ My Research Assistant : Bring the power of the Web of Science to your mobile device, wherever inspiration strikes. Glioma stem cells (GSCs) have a high capacity for self-renewal, invasion, and survival.

Glioma stem cells promote radioresistance by preferential activation of the dna damage response

McLendon et al., "Glioma stem cells promote radioresistance by preferential activation of the DNA damage response," Nature, vol. The Role of Microglia and Macrophages in CNS Homeostasis, Autoimmunity, and Cancer 2006-10-18 · The mechanisms underlying tumour radioresistance have remained elusive. Here we show that cancer stem cells contribute to glioma radioresistance through preferential activation of the DNA damage Here we show that cancer stem cells contribute to glioma radioresistance through preferential activation of the DNA damage checkpoint response and an increase in DNA repair capacity. The fraction of tumour cells expressing CD133 (Prominin-1), a marker for both neural stem cells and brain cancer stem cells, is enriched after radiation in gliomas. Here we show that cancer stem cells contribute to glioma radioresistance through preferential activation of the DNA damage checkpoint response and an increase in DNA repair capacity. The fraction of tumour cells expressing CD133 (Prominin-1), a marker for both neural stem cells and brain cancer stem cells, is enriched after radiation in gliomas. Here we show that short-term cultures of glioma xenografts subjected to three serial cancer stem cells contribute to glioma radioresistance through cycles of IR also contained greater percentages of CD1331 cells than preferential activation of the DNA damage checkpoint response parental populations (Supplementary Fig. S2). The mechanisms underlying tumour radioresistance have remained elusive.

Here we show that cancer stem cells contribute to glioma radioresistance through preferential activation of the DNA damage checkpoint response and an increase in DNA repair capacity. The fraction of tumour cells expressing CD133 (Prominin-1), a marker for both neural stem cells and brain cancer stem cells, is enriched after radiation in gliomas.

2019-02-05 · Glioma stem cells promote radioresistance by preferential activation of the DNA damage response Nature , 444 ( 2006 ) , pp. 756 - 760 CrossRef View Record in Scopus Google Scholar In this study, CD133 (a marker of brain cancer stem cells) and nestin were co-expressed in GSCs isolated from GCs. The percent of CD133+ cells in GSCs and GCs were >80 and 2%, respectively.

Glioma stem cells promote radioresistance by preferential activation of the DNA damage response. Shideng Bao, et al., Nature, 444:756 (2006) Speaker :

Glioma stem cells promote radioresistance by preferential activation of the DNA damage response Bao S, Wu Q, McLendon RE, Hao Y, Shi Q, Hjelmeland AB, Dewhirst MW, Bigner DD, Rich JNGlioma stem cells promote radioresistance by preferential activation of the DNA damage response.

We have examined DNA repair in five stem and nonstem glioma cell lines. The population doubling time was … Comparative analysis of DNA repair in stem and nonstem glioma cell cultures. It has been reported that cancer stem cells may contribute to glioma radioresistance through preferential activation of the DNA damage checkpoint response and an increase in DNA repair capacity. We have examined DNA repair in five stem and nonstem glioma cell lines. Cancer stem cells contribute to glioma radioresistance by an increase of DNA repair capacity through preferential activation of the DNA damage response checkpoints. Potential therapies that modulate or target cancer stem cells are also reviewed.
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Nature. 444, 756-760 (2006).

24 Mar 2021 Glioma stem cells promote radioresistance by preferential activation of the DNA damage response.
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Glioma stem-like cells (GSCs) are recognized as a special population of GBM cells that contributes to tumorigenesis, radiochemoresistance, and recurrence [6-9]. Developing new therapeutic drugs combined with conventional therapy is strongly needed for GBM patients.

S Bao, Q Wu, RE McLendon, Y Hao, Q Shi, AB Hjelmeland, The ability to prospectively distinguish glioma stem cells, which reside at the Similarly, glioma CSCs preferentially express the IL-6 receptor, which also promotes Cancer cells often activate redundant angiogenic pathways in res Collectively, glioblastoma offers a reliable cancer to study cancer stem cells (A) Critical epigenetic regulators drive GSC maintenance and response to cells promote radioresistance by preferential activation of the DNA damage res 21 Jun 2019 The cellular response to DNA damage is a complex process Rich, J.N. Glioma stem cells promote radioresistance by preferential activation of 1 Sep 2018 A consistent feature of the GSC and cancer stem cell DDR phenotype is the upregulation and/or constitutive activation of multiple components of both the DNA repair radiation resistance in relatively radiosensitive non-G brain tumors select for and induce a more stem-like population of cells that can activation of the DNA damage response. The CD133+ Glioma stem cells promote radioresistance by preferential activation of the DNA damage response. Glioma stem cells promote radioresistance by preferential activation of the DNA damage response. Nature.

Here we show that cancer stem cells contribute to glioma radioresistance through preferential activation of the DNA damage checkpoint response and an increase in DNA repair capacity. The fraction of tumour cells expressing CD133 (Prominin-1), a marker for both neural stem cells and brain cancer stem cells, is enriched after radiation in gliomas.

Nature 2006;444:756-60. Liu G, Yuan X, Zeng Z, et al. Analysis of gene expression and chemoresistance of CD133+ cancer stem cells in glioblastoma. Mol Cancer 2006;5:67.

The fraction of tumour Glioma stem cells promote radioresistance by preferential activation of the DNA damage response. Bao S, Wu Q, McLendon RE, Hao Y, Shi Q, Hjelmeland AB, Dewhirst MW, Bigner DD, Rich JN. Nature. 2006 Dec 7;444(7120):756-60. Epub 2006 Oct 18.